neurodegenerative diseases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1880	P7C3		Others
	The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be...		Others
T8849	PF-9601N		MAO
	PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD.		MAO
T3707	GNE-3511	GNE3511	DNA Alkylation , MAPK
	GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.		DNA Alkylation , MAPK
T5728	OsMundacetone	4-(3,4-Dihydroxyphenyl)-3-buten-2-one	Apoptosis , Reactive Oxygen Species
	OsMundacetone (4-(3,4-Dihydroxyphenyl)-3-buten-2-one) is a natual product isolated from Rhizoma osmundae.		Apoptosis , Reactive Oxygen Species
T9776	TRPM4 inhibitor 8		TRP/TRPV Channel
	TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.		TRP/TRPV Channel
T3026	(-)-Huperzine A	HupA,Huperzine A	Apoptosis , AChR , AChE , iGluR
	(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the tr...		Apoptosis , AChR , AChE , iGluR
T22911	β-N-methylamino-L-alanine hydrochloride	L-BMAA hydrochloride	Others
	β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. L-BMAA hydrochloride could cause amyotrophic lateral sclerosis (ALS) and possibly other neurodegenerative diseases...		Others
T9999	Sirtuin modulator 2	N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide	Others , Sirtuin
	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.		Others , Sirtuin
T25531	IND24	IND-24,IND 24	Antiviral
	IND24 has anti-prion activity and can be used to study neurodegenerative diseases.		Antiviral
T10980	DCPLA-ME	Methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoate,2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester,Methyl 8-(2-((2-pentylcyclopropyl)methyl)cyclopropyl)octanoate,DCPLA methyl ester	PKC
	DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerative diseases. It is an effective PKCε activator.		PKC
T60932	MAO-B-IN-8		MAO
	MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neuroinflammatory mediators. This compound is specifically des...		MAO
T73270	GSK3-IN-2		GSK-3
	GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.		GSK-3
T2999	Gastrodin	Gastrodine	Others
	Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases.		Others
T77708	Casein kinase 1δ-IN-7		Casein Kinase
	Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.		Casein Kinase
T83646	(S)-OSMI 3	Ent-OSMI-3	Others
	(S)-OSMI 3 (Ent-OSMI-3) has anti-inflammatory and anti-tumour activity and can be used to study diabetes and neurodegenerative diseases.		Others
T62750	TREM2 agonist-2		Others
	TREM2 agonist-2 (I-192) is an orally active and potent myeloid triggered receptor 2 (TREM2) agonist for the study of neurodegenerative diseases.		Others
T38654	Cotosudil		ROCK
	Cotosudil is a ROCK kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or neurodegenerative diseases or nerve damage.		ROCK
T72073	AKOS037652256
	AKOS037652256 can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity such as lysosomal accumulation disorders, muscular dystrophy, common age-related neurodegenerative diseases, oxi...
T77709	Casein kinase 1δ-IN-8		Casein Kinase
	Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.		Casein Kinase
T10012	P7C3-OMe		Others
	P7C3-OMe, a pro-neurogenic agent, has therapeutic benefits in neurodegenerative diseases. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer.		Others